Are you using the Office 2010 public beta? It’s pretty darn stable and I’ve been using it since November. One thing I like in particular about Outlook 2010 is that the Navigation Pane font can be changed directly at long last. No longer are you stuck with the default 8 point font, or having to experiment with system fonts to see which one affects the list, and then trying to find something that works here while not breaking something else.
At the bottom of the Navigation Pane, click the Configure buttons dropdown arrow, shown below, and then click Navigation Pane Options.
In the Navigation Pane Options dialog box, click Font. Finally, in the Font dialog box, choose a font and size that work better for your vision, assuming that Segoe UI 8 isn’t something you’d choose.